Metastasis of triple negative breast cancer is regulated by a targetable miR-342-E2F network

Abstract

Triple-negative breast cancer (TNBC) has a high incidence of metastasis and limited therapeutic options. Here, we identify a multimodal and targetable miR-342-E2F network that regulates metastatic outgrowth in TNBC. Through integrating clinical and experimental datasets, we uncover miR-342 as a suppressor of TNBC metastasis. Temporal re-expression of miR-342 significantly inhibited metastatic progression in both immunocompetent and xenograft TNBC models by specifically limiting the outgrowth of disseminated tumour cells. Using multi-omics profiling, we identified the global complement of miR-342 targets, demonstrating that it directly suppresses transcriptional and post-transcriptional netwo..